Since 1980s, Chinese companies have begun to use the fermentation process to produce long-chain dicarboxylic acids at a small scale. Since the 1990s, they have mainly produced tridecanedioic acid. Now, China has had a total tridecanedioic acid capacity of 300t/a, of which Shanghai INDA Electromechanics Co. Ltd. occupies 200t/a and Fushun Petrochemical Research Institute 100t/a. After the Institute of Microbiology, Chinese Academy of Sciences developed a fermentation technology to produce long-chain dicarboxylic acids using wax oil as substrate and successfully realized the industrial production of long-chain dicarboxylic acids with this technology in 2005, China has become the world's only country which has achieved the large-scale industrial production of several long-chain dicarboxylic acids with the microbiological technology. The fermentation method is to produce dicarboxylic acids in the particles of cells. Compared with the chemical synthesis method, the fermentation method has a simple process, mild production conditions, high yield, low costs and no pollution, and its entire production process is carried out under normal temperature and pressure...............

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